Latest App Notes & Case Studies

PBMCs are routinely isolated and frozen down for experimental use, but what impact does cryopreservation have on these cells?

Expansion of Specific Lymphocyte Populations With 4Cell® Nutri-T Xeno-Free, Serum-Free Medium

The success of CAR T-cell therapy requires efficient expansion of specific subpopulations of patient-derived immune cells.

There are currently more than 140 monoclonal antibodies (mAbs) approved by the FDA as biotherapeutic agents, representing the most rapidly growing class of new drugs.

Hybridization capture-based target enrichment employs probes to select sequences of interest in a next generation sequencing (NGS) library.

Despite daily use in every life science laboratory, best pipetting practices are not as well-known as one might expect. Many users are self-taught and have never received formal pipetting training during their professional career.

Highly ordered protein aggregates, termed amyloid fibrils, are associated with a broad range of diseases, many of which are neurodegenerative for example Alzheimer’s and Parkinson’s. The transition from soluble, functional protein to insoluble amyloid fibril occurs via a complex process involving the initial generation of highly dynamic early stage aggregates or prefibrillar species.

Download this application focus to learn more about the solutions available to optimize the sensitivity of viral detection.

Large-insert libraries require specific quality conditions of the starting genomic DNA (gDNA) material for successful outcomes. Physical, enzymatic and chemical shearing of gDNA into smaller fragments can occur at many different points during extraction and handling of gDNA.

Discovery of novel immunotherapies that specifically target and enhance the T cell response against cancer is a rapidly expanding research area. Robust and relevant in vitro models for evaluation of these immunotherapies is essential throughout their development.

Download this app note to learn more about how saturation mutagenesis can be used to identify functional GPCR variants, why error-prone PCR results in low variant representation as well as the advantages of synthetic saturation mutagenesis libraries.