Drug Kinetics – Webinars and Online Events

Watch this webinar to learn more about applications for screening and characterizing antibody and antibody fragments plus a label-free technology which uses surface plasmon resonance (a biophysical technology) for characterizing antibodies.

This webinar highlights the latest affinity chromatography solutions for the quick and easy purification of multiple AAV serotypes across a variety of column setups.

In the webinar, we discuss a suite of metabolic stability assays developed using an AEMS system.

With unrivaled flexibility and high sensitivity, the WAVE brings label-free quantification to a whole new world of applications, revolutionizing the study of biomolecular interactions.

Studies on drug metabolism aid in evaluating the pharmacokinetics, pharmacodynamics and safety during discovery and development.

As a cornerstone of genetic analysis in biological research, quantitative PCR (qPCR) and digital PCR (dPCR) are the most sensitive molecular methods to analyze nucleic acids and play a key role in the development of cell and gene therapies (CGT).

These tools are widely used during CGT development for example in biodistribution, pharmacokinetics and pharmacodynamics of the investigational lead molecule. But many samples, including tissues rich in nucleases, lipids and other inhibiting substances and target molecules that are short or contain modified bases, can be challenging to work with. For these types of samples, assay design using advanced strategies, concentration standards, spike-in controls and validated normalization is key for reliable analyses.

In this webinar, Dr. Kubista will present strategies for implementing reliable qPCR and dPCR analysis in CGT development while highlighting best practices for adhering to MIQE and dMIQE guidelines and the recently released ISO standard, ISO 20395:2019.

The administration of drugs via inhalation into the lungs is superior to many other methods of delivery because our lungs provide a large surface area for absorption, access to the whole blood volume and comparatively little metabolic activity. Currently, there are limited in vitro models in which the absorption and permeability of drugs across the lung and into systemic circulation can be precisely measured.

In this webinar, Dr. Emily Richardson will describe novel lung-on-a-chip (LOAC), otherwise known as lung microphysiolological system, models of the alveoli and bronchi which can be used to accurately predict drug pharmacokinetics, allowing for more rapid, precise and cost-effective analysis of compounds.

An integrated evaluation of the pharmacodynamic and pharmacokinetic properties of a drug is essential for successful translation to the clinic. However, cost-effective methods to measure these parameters at the systems level in pre-clinical models are lacking. Here, we introduce a timsTOF and MALDI-2 workflow to evaluate therapeutic activity. The platform combines ion mobility, mass spectrometry-based imaging, absolute drug quantitation across different biological matrices, in vivo isotope tracing, and global metabolome analysis in the adult zebrafish.

We will explore how these advances are being utilized, both individually and in tandem, as we discuss a variety of new applications demonstrating the benefits of this improved, fully integrated system.

We will explore how these advances are being utilized, both individually and in tandem, as we discuss a variety of new applications demonstrating the benefits of this improved, fully integrated system.