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This poster highlights the latest spatial biology solutions for GBM tissue analysis, offering critical insights into the metabolic signatures and immune cell infiltration of this tissue type.

Despite the valuable transcriptomic information provided by probe-based spatial assays, detecting immune cell infiltration can pose challenges

Liquid biopsy for profiling of cell free DNA (cfDNA) in blood holds huge promise to transform how we experience and manage cancer by early detection and identification of residual disease and subtype. However, a standard blood draw yields an average of only 10 ng of cfDNA, of which DNA derived from the tumor is a small minority.

Researchers require spatial information and high-plex gene expression data to understand how cells interact with tumors. However, molecular subtyping within a tumor type requires additional stratification at the tissue level to facilitate meaningful subsequent gene expression analysis.

In tumors, metabolic shifts cause increased glucose uptake and fermentation. Traditionally, bulk analysis has been used to measure tumor metabolism, however, all tumors show some heterogeneity, and only an average measurement is produced by bulk analysis.

Highly multiplexed spatial biomarker analysis has demonstrated the potential to advance our current understanding of the immune system and its role in cancer.

T cells can develop an exhausted phenotype due to prolonged antigen stimulation, resulting in reduced proliferative potential and loss of cytotoxic funtion. This can occur within the tumor microenvironment, allowing cancer cells to escape immune surveillance.

Insights and Expanding Practical Education in a Core Facility With Brightfield Imaging-Enabled Flow Cytometry

The diversity of potential mRNA-based therapies has led to increased interest in using synthetic mRNA as a tool in the treatment of multiple diseases. Nevertheless, obtaining larger quantities of synthetic mRNA for clinical treatment remains a challenge.

The potential of human pluripotent stem cells (hPSCs) continues to show incredible promise, rapidly progressing through clinical trials for use in treatment of a multitude of diseases. However, historical methods of hPSC culture have remained a barrier of entry into the clinic even with relative success within in vitro cellular research.